关于赛尔

关于赛尔

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    强大专业的研发团队由具有医学、生物学、药学、中医学、生物信息学、农学、兽医学、化学及生物工程等多学科专业技术人员组成,具有资深科研背景,丰富的研究经历,市场和项目经理及项目负责人均具有博硕士学位。
    主要从事细胞生物学,分子生物学,肿瘤学,免疫学等方面研究。曾赴瑞典做博士后研究,研究方向为癌症的基因治疗。在赛尔生物工作十余年,现担任天津赛尔生物技术有限公司市场总监,擅长生物医学SCI课题咨询,设计与分析。  
  已发表主要学术论文:
1. NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells[J]. Journal of Translational Medicine, 2014, 12(1):1-14.(SCI IF: 3.93)
2. MicroRNA-16 targets zyxin and promotes cell motility in human laryngeal carcinoma cell line HEp-2[J]. International Union of Biochemistry & Molecular Biology Life, 2011, 63(2):101-8.(SCI IF: 3.143)
3. Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma[J]. Cell Research, 2009, 19(7):828-837.(SCI IF: 14.812)
  毕业于天津医科大学,医学背景,特别擅长各种原代细胞的培养,病毒学,肿瘤学,RNA干扰,裸鼠模型及药物评价,抗体,细胞分子生物学等方面研究。  
    已发表主要学术论文:
1. miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells. Cancer Lett. 2013, Mar 4.(SCI IF: 4.238)
2. ICP4-induced miR-101 attenuates HSV-1 replication. Scientific Reports. 2016, Feb 26.
(SCI IF: 5.578)
3. PTTG1-targeting miRNAs, miR-329, miR-300, miR-381, and miR-655 mapped to the 14q32.31 locus, inhabits pituitary tumor cell tumorigensis and were involved in a p53/PTTG1 regulation feedback loop. Oncotarget. 2015, Oct 6.(SCI IF: 6.359)
  博士期间成绩优异,曾获留学基金支持,赴美国Tufts university 留学深造,特别擅长 miRNA,肿瘤,生物信息学, 蛋白修饰,基因表达调控,细胞分子生物学,肿瘤学等方面研究。  
  已发表主要学术论文:
1. Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells. IUBMB Life, 2013. 65(12): 1026-34.(SCI IF: 3.143)
2. miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively. Sci Rep, 2015. 5: 15793.(SCI IF: 5.578)
    毕业于天津医科大学,病原生物学博士。特别擅长病毒学,表观遗传学,免疫学,非编码RNA,基因表达调控,细胞分子生物学,病毒学,免疫学等方面研究。  
  已发表主要学术论文:
1. ICP4-induced miR-101 attenuates HSV-1 replication. Sci Rep. 2016 Mar 17;6:23205. (SCI IF: 5.578)
2. DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells. J Biol Chem. 2014 Aug 29;289(35):24724-35.(SCI IF: 4.573)
3. KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells. Oncotarget. 2016 Jul 25;10.18632.(SCI IF: 5.008)
4. miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells. Br J Cancer. 2016 Aug 18. doi: 10.1038/bjc.2016.244. (SCI IF: 5.569)
5.miR-429 is involved in regulation of NF-κBactivity by targeting IKKβ and suppresses oncogenic activity in cervical cancer cells.FEBS Lett. 2017 Jan;591(1):118-128.doi: 10.1002/1873-3468.12502. Epub 2016 Dec 20.(SCI IF: 3.519)